エボラ熱ワクチンの初期試験で免疫反応 イギリスの製薬大手が開発

英製薬大手グラクソ・スミスクライン(GSK)
Open Image Modal
Reuters

英製薬大手グラクソ・スミスクライン(GSK)

初期臨床試験は英国で昨年9月17日から11月18日の間に、健康なボランティア60人を対象に実施、結果がこのほど医学誌「ニューイングランド・ジャーナル・オブ・メディスン」に掲載された。

フェーズIの主な目的はワクチンの安全性を確かめることだった。オックスフォード大学ジェンナー研究所で試験を率いたエイドリアン・ヒル氏はロイターに対し、ワクチンが免疫系からの反応も促進することが示されたことは「心強い」と述べた。その上で「安全性はほぼわれわれが期待した通りで、免疫反応はまずまずだがすごいとは言えない」と説明した。

副作用についてヒル氏は「1─2日続く痛みあるいは接種箇所が赤くなるなどの軽い症状がほとんどで、たまに微熱が出る場合があった」と述べた。ただ、抗体反応は、マカクザルを対象に同じワクチンを接種した場合と比べて弱かったと指摘した。

[ロンドン 28日 ロイター]

関連記事

Ebola Outbreak
(01 of11)
Open Image Modal
A member of Doctors Without Borders puts on protective gear at the isolation ward of the Donka Hospital in Conakry, where people infected with the Ebola virus are being treated. (Cellou Binani/AFP/Getty Images)
(02 of11)
Open Image Modal
Health specialists work at an isolation ward for patients at the Doctors Without Borders facility in Gueckedou, southern Guinea. (Seyllou/AFP/Getty Images)
(03 of11)
Open Image Modal
Doctors Without Borders staff members carry the body of a person killed by viral haemorrhagic fever at a center for victims of the Ebola virus in Gueckedou, on April 1, 2014. (Seyllou/AFP/Getty Images)
(04 of11)
Open Image Modal
Health specialists work in an isolation ward for patients at the Doctors Without Borders facility in Gueckedou, southern Guinea. (Seyllou/AFP/Getty Images)
(05 of11)
Open Image Modal
A view of gloves and boots used by medical staff, drying in the sun, at a center for victims of the Ebola virus in Gueckedou, on April 1, 2014. (Seyllou/AFP/Getty Images)
(06 of11)
Open Image Modal
A 10-year-old boy is showered after being taken out of quarantine following his mother\'s death caused by the Ebola virus, in the Christian charity Samaritan\'s Purse Ebola treatment center at the ELWA hospital in the Liberian capital Monrovia, on July 24, 2014. (Zoom Dosso/AFP/Getty Images)
(07 of11)
Open Image Modal
A health specialist works in a laboratory set up in a tent at an isolation ward for patients at the Doctors Without Borders facility in Gueckedou, southern Guinea. (Seyllou/AFP/Getty Images)
(08 of11)
Open Image Modal
View of an isolation center for people infected with Ebola at Donka Hospital in Conakry. (Cellou Binani/AFP/Getty Images)
(09 of11)
Open Image Modal
A worker loads material including protection gear for Doctors Without Borders at the airport of Conakry on March 29, 2014. (Cellou Binani/AFP/Getty Images)
(10 of11)
Open Image Modal
The owners of a \"maquis,\" a small African restaurant in Kobakro, outside Abidjan, which used to serve bush meat, hold up the different types of meat and fish they now offer to their clients. The Ministry of Health has asked Ivorians, \"particularly fond of porcupine and agouti,\" a small rodent, to avoid consuming or handling bushmeat, as an unprecedented Ebola epidemic hit West Africa. The virus can spread to animal primates and humans who handle infected meat -- a risk given the informal trade in \"bushmeat\" in forested central and west Africa. (Issouf Sanogo/AFP/Getty Images)
(11 of11)
Open Image Modal
A pharmacist searches for drugs in a pharmacy in Lagos on July 26, 2014. Nigeria was on alert against the possible spread of Ebola on July 26, a day after the first confirmed death from the virus in Lagos, the country\'s financial capital and Africa\'s biggest city. The health ministry said Friday that a 40-year-old Liberian man died at a private hospital in Lagos from the disease, which has now killed more than 650 people in four west African countries since January. (Pius Utomi Ekpei/AFP/Getty Images)